mgh.harvard.edu.2Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States.3Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, United States; Harvard Medical School, Boston, MA, United States.4Department of Biostatistics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.AbstractBACKGROUND:

Correlates of cannabis use and dependence among young adults have been widely studied. However, it is not known which factors are most strongly associated with severity of cannabis use dependence (CUD) severity. Identification of the salient correlates of CUD severity will be of increasing clinical significance as use becomes more socially normative.

METHODS:

This study used a data-driven, hypothesis-free approach to examine the most robust correlates of CUD severity among a sample of 76 young adults (ages 18 to 25 years) who used cannabis at least weekly. Seventy-one candidate variables were examined for association with CUD severity. These included demographic variables, self-reported and psychodiagnostic assessments of mood and anxiety, self-reported measures of personality, cannabis and other substance use characteristics, and objective and subjective measures of cognition.

RESULTS:

Of the 71 candidate variables considered, 27 were associated with CUD severity on a univariate level at a p-value

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