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The effects of marijuana smoking on lung function in older people.

Eur Respir J. 2019 Sep 19;:

Authors: Tan WC, Bourbeau J, Aaron SD, Hogg JC, Maltais F, Hernandez P, Marciniuk DD, Chapman KR, To T, FitzGerald JM, Walker BL, Road J, Zheng L, Zhou G, Yau T, Benedetti A, O’Donnell D, Sin DD, CanCOLD Collaborative Research Group

Abstract
BACKGROUND: Previous studies have associated marijuana exposure with increased respiratory symptoms and chronic bronchitis among long-term cannabis smokers.The long-term effects of smoked marijuana on lung function remain unclear.
METHODS: We determined the association of marijuana smoking with the risk of spirometrically-defined COPD [post-bronchodilator FEV1/FVC<0·7] in 5291 population-based individuals and the rate of decline in FEV1 in a subset of 1285 men and women, aged 40 years and older, who self-reported use (or nonuse) of marijuana and tobacco cigarettes and performed spirometry before and after inhaled bronchodilator on multiple occasions. Analysis for the decline in FEV1 was performed using random mixed effects regression models adjusted for age, gender, and body mass index. Heavy tobacco smoking and marijunana smoking was defined as >20 pack-years and >20 joint-years, respectively.
RESULTS: Approximately 20% of participants had been or were current marijuana smokers with most also having smoked tobacco cigarettes (83%). Among heavy marijuana users, the risk of COPD was significantly increased (adjusted odds ratio, aOR, 2.45; 95% CI, 1.55-3.88). Compared to never-smokers of marijuana and tobacco, heavy marijuana smokers and heavy tobacco smokers experienced a faster decline in FEV1 by 29·5 mL·year-1 (p=0·0007) and 21·1 mL·year-1 (p<0.0001), respectively.Those who smoked both experienced a decline of 32.31 mL·year-1 (p<.0001).
INTERPRETATION: Heavry marijuana smoking increases the risk of COPD and accelerates FEV1 decline in concomitant tobacco smokers beyond that observed with tobacco alone.

PMID: 31537703 [PubMed – as supplied by publisher]


Source: ncbi 2

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