Evaluation of Latent Fingerprints for Drug-Screening In A Social Care Setting.
J Anal Toxicol. 2020 Dec 02;:
Authors: Pollard C, Sievers C, Royall PG, Wolff K
Sweat deposited via Latent Fingerprints (LFPs) was previously used to detect cocaine, opioids, cannabis and amphetamine via a point-of-care test (POCT). This screening method combined non-invasive sampling with a rapid result turnaround to produce a qualitative result outside of the laboratory. We report the novel application of a LFP drug screening test in a social care setting. Clients were tested on either an ad-hoc or routine basis using the POCT DOA114 (Intelligent Fingerprint Ltd.) drug screening cartridge. Screening cut-off values were 45, 35 and 95 pg/fingerprint for benzoylecgonine (BZE), morphine and amphetamine analytes, respectively. Confirmation LFP samples (DOA150, Intelligent Fingerprinting Ltd.) and oral fluid (OF) were analysed using UPLC-MS/MS. Thirty-six clients aged 36 ± 11 years participated (53% females). Individuals self-reported alcohol consumption (39%) and smoking (60%). Of 131 screening tests collected over 8 weeks: 14% were positive for cocaine; 2% for opioids; 1% amphetamine. Polydrug use was indicated in 10% of tests. Of 32 LFP confirmation tests, 63% were positive for cocaine and BZE. Opioids were also detected (31%) with the metabolite 6-monoacetylmorphine (6-MAM) being the most common (16%). In OF, cocaine was the dominant analyte (9%) followed 6-MAM (5%). Comparing positive LFP screening tests with positive OF samples found 39% and 38% were cocaine and opiate positive respectively. Out of the drugs screened for via the LFP POCT, cocaine was the most prevalent analyte in LFP and OF confirmation samples. The study is a step change in the routine drug screening procedures in a social care setting: especially useful for on-site cocaine detection in clients whose drug use was being monitored. Additionally, testing was easily accepted by clients and social care workers.
PMID: 33263738 [PubMed – as supplied by publisher]
Source: ncbi 2