Manipulation of Cannabinoid Biosynthesis <em>via</em> Transient RNAi Expression

Front Plant Sci. 2021 Dec 10;12:773474. doi: 10.3389/fpls.2021.773474. eCollection 2021. ABSTRACT Cannabis sativa L. produces unique phytocannabinoids, which are used for their pharmaceutical benefits. To date, there are no reports of in vivo engineering targeting the cannabinoid biosynthesis genes to greater elucidate the role each of these genes play in Read more…

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Evaluation of the effectiveness of a school-based alcohol and cannabis prevention programme among adolescents.

Rev Esp Salud Publica. 2022 Jan 17;96:e202201004. ABSTRACT OBJECTIVE: Alcohol and cannabis consumption in young people aged 14 to 18 years show high and stable prevalence and incidence. The Instituto de Adicciones de Madrid Salud (IAMS) within its prevention strategy aimed at adolescents and young people in Madrid, implements an Read more…

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A Survey of Cannabis Use in a Large US-Based Cohort of People with Multiple Sclerosis

Int J MS Care. 2021 Nov-Dec;23(6):245-252. doi: 10.7224/1537-2073.2021-036. Epub 2021 Dec 29. ABSTRACT BACKGROUND: As cannabis products become increasingly accessible across the United States, it is important to understand the contemporary use of cannabis for managing multiple sclerosis (MS) symptoms. METHODS: We invited participants with MS from the North American Read more…

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Assessing the impact of a cannabis course on pharmacy students' understanding, beliefs and preparedness regarding medical and recreational cannabis

Can Pharm J (Ott). 2021 Sep 3;155(1):50-59. doi: 10.1177/17151635211041041. eCollection 2022 Jan-Feb. ABSTRACT BACKGROUND: With the legalization of cannabis in Canada in 2018, pharmacists are increasingly likely to encounter patients using this substance. The primary objective of this pre-post questionnaire study was to evaluate the impact of an accredited cannabis Read more…

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Rapid Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method to Measure Cannabinoids in Bronchoalveolar-Lavage Fluid of Patients with e-Cigarette, or Vaping, Product Use-Associated Lung Injury

ACS Omega. 2021 Dec 30;7(1):443-452. doi: 10.1021/acsomega.1c04815. eCollection 2022 Jan 11. ABSTRACT In 2019, the Centers for Disease Control and Prevention responded to an outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI). Bronchoalveolar-lavage (BAL) fluid from EVALI patients was available for analysis to investigate a range of potential Read more…

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Cannabis Vapor Exposure Alters Neural Circuit Oscillatory Activity in a Neurodevelopmental Model of Schizophrenia: Exploring the Differential Impact of Cannabis Constituents

Schizophr Bull Open. 2021 Nov 20;3(1):sgab052. doi: 10.1093/schizbullopen/sgab052. eCollection 2022 Jan. ABSTRACT Cannabis use is highly prevalent in patients with schizophrenia and worsens the course of the disorder. To understand how exposure to cannabis changes schizophrenia-related oscillatory disruptions, we investigated the impact of administering cannabis vapor containing either Δ9-tetrahydrocannabinol (THC) Read more…

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Marijuana toxicosis in 2 donkeys

J Vet Diagn Invest. 2022 Jan 17:10406387211064269. doi: 10.1177/10406387211064269. Online ahead of print. ABSTRACT Marijuana toxicosis is typically seen by companion animal veterinarians. However, with increased marijuana availability, there is a greater potential for toxicosis in other species. Herein we describe a case of suspected marijuana toxicosis in a female Read more…

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Clinical effects of a single dose of cannabinoids to patients with chronic lymphocytic leukemia

Leuk Lymphoma. 2022 Jan 17:1-11. doi: 10.1080/10428194.2021.2020776. Online ahead of print. ABSTRACT This phase II clinical trial investigates a one-time oromucosal dose of tetrahydrocannabinol/cannabidiol (THC/CBD) in 23 patients with indolent leukemic B cell lymphomas. Primary endpoint was a significant reduction in leukemic B cells. Grade 1 – 2 adverse events Read more…

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Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies

J Vis Exp. 2021 Dec 29;(178). doi: 10.3791/63228. ABSTRACT With increased attention on cannabinoids in medicine, several mammalian model organisms have been used to elucidate their unknown pharmaceutical functions. However, many difficulties remain in mammalian research, which necessitates the development of non-mammalian model organisms for cannabinoid research. The authors suggest Read more…

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Gramene: A Resource for Comparative Analysis of Plants Genomes and Pathways

Methods Mol Biol. 2022;2443:101-131. doi: 10.1007/978-1-0716-2067-0_5. ABSTRACT Gramene is an integrated bioinformatics resource for accessing, visualizing, and comparing plant genomes and biological pathways. Originally targeting grasses, Gramene has grown to host annotations for over 90 plant genomes including agronomically important cereals (e.g., maize, sorghum, wheat, teff), fruits and vegetables (e.g., Read more…

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