Cannabinoid concentrations in confiscated cannabis samples and in whole blood and urine after smoking CBD-rich cannabis as a « tobacco substitute ».

irm.unibe.ch.3Institute of Forensic Medicine, Department of Traffic Sciences, University of Bern, Sulgenauweg 40, 3007, Bern, Switzerland.Abstract In Switzerland, only cannabis with a total Δ9-tetrahydrocannabinol (THC) content higher than 1% is controlled by the narcotics legislation. Cannabis products rich in cannabidiol (CBD) and low in THC can be legally sold as Read more…

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Validation of a liquid chromatography-tandem mass spectrometry method for analyzing cannabinoids in oral fluid.

ucsd.edu.2Department of Pathology, Center for Advanced Laboratory Medicine, University of California, San Diego Health, San Diego, CA, USA; Insource Diagnostics, Monrovia, CA, USA.3Department of Pathology, Center for Advanced Laboratory Medicine, University of California, San Diego Health, San Diego, CA, USA.Abstract A liquid chromatography tandem mass spectrometry method was developed for Read more…

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Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids.

5-fold, however the mechanisms by which T2D increases dementia risk remain unclear. Evidence suggests that the heightened inflammation and oxidative stress in T2D may lead to disruption of the blood-brain barrier (BBB), which precedes premature cognitive decline. Studies show that vascular-targeted anti-inflammatory treatments protect the BBB by attenuating neuroinflammation, and Read more…

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Why marijuana is headed for the mainstream.

Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials Submit Data Resources Chemicals & BioassaysData & SoftwareDNA & RNADomains & StructuresGenes & ExpressionGenetics & MedicineGenomes & MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyVariation Popular PubMed Bookshelf PubMed Central BLAST Nucleotide Genome SNP Gene Protein PubChem Featured Genetic Testing Registry Read more…

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Epidiolex (Cannabidiol): A New Hope for Patients With Dravet or Lennox-Gastaut Syndromes.

2 years old with DS and LGS and is well tolerated. KEYWORDS: CBD; Dravet; Epidiolex; GWP42003-P; Lennox-Gastaut; antiseizure medications; cannabidiol; epilepsy; seizure; treatment-resistant epilepsy PMID: 30616356 DOI: 10.1177/1060028018822124 ShareLinkOut – more resourcesFull Text SourcesAtypon Supplemental Content Full text links View the Original article Partage le savoir

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Special Considerations and Assessment in Patients with Multiple Sclerosis.

tuhs.temple.edu.2Department of Physical Medicine and Rehabilitation, Lewis Katz School of Medicine, Temple University, 3401 North Broad Street, Philadelphia, PA 19140, USA.Abstract Multiple sclerosis is a progressive autoimmune neurologic disorder that may affect any region of the central nervous system. Spasticity in patients with multiple sclerosis can be debilitating and detrimental Read more…

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Preclinical safety and efficacy of cannabidivarin for early life seizures.

georgetown.edu.Abstract A significant proportion of neonatal and childhood seizures are poorly controlled by existing anti-seizure drugs (ASDs), likely due to prominent differences in ionic homeostasis and network connectivity between the immature and mature brain. In addition to the poor efficacy of current ASDs, many induce apoptosis, impair synaptic development, and Read more…

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