Acute effects of ∆9-tetrahydrocannabinol (THC) on resting state brain function and their modulation by COMT genotype.

umcutrecht.nl.2Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.3Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, Read more…

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Selective activation of cannabinoid receptor-2 reduces neuroinflammation after traumatic brain injury via alternative macrophage polarization.

augusta.edu.Abstract Inflammation is an important mediator of secondary neurological injury after traumatic brain injury (TBI). Endocannabinoids, endogenously produced arachidonate based lipids, have recently emerged as powerful anti-inflammatory compounds, yet the molecular and cellular mechanisms underlying these effects are poorly defined. Endocannabinoids are physiological ligands for two known cannabinoid receptors, CB1R Read more…

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Preliminary results from a pilot study examining brain structure in older adult cannabis users and nonusers.

ucsd.edu.2Department of Psychology & Neuroscience, University of Colorado Boulder, 345 UCB, Boulder, CO, United States.Abstract Exploring associations among cannabis use, brain structure, and cognitive function in older adults offers an opportunity to observe potential harm or benefit of cannabis. This pilot study assessed structural magnetic resonance imaging in older adults Read more…

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Cannabis use and human retina: The path for the study of brain synaptic transmission dysfunctions in cannabis users.

univ-lorraine.fr.2Pôle Hospitalo-Universitaire de Psychiatrie d’Adultes du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France; INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Département de Psychiatrie, Centre Hospitalier Régional Universitaire de Strasbourg, Strasbourg, France; Maison des Addictions, CHRU Nancy, Nancy, France.3Service d’Ophtalmologie, CHRU Nancy, Nancy, France.4INSERM U1114, Fédération de Médecine Translationnelle Read more…

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Increased expression of cannabinoid CB2 and serotonin 5-HT1A heteroreceptor complexes in a model of newborn hypoxic-ischemic brain damage.

Augmentation de l’expression des cannabinoïdes CB2 et sérotoninergique 5-HT1A heteroreceptor complexes dans un modèle de nouveau-né hypoxique-ischémique des lésions cérébrales. Franco R1, M2 Villa, Morales P3, Reyes-Resina I4, Gutiérrez Rodríguez A2, J4 Jiménez, Jagerovic N3, Martínez-Orgado J5, Navarro G6. L’auteur information1Centro de Investigación en rouge, Enfermedades Neurodegenerativas (CIBERNED). Instituto de Read more…

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