Δ9-tetrahydrocannabinol leads to Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Human BeWo Trophoblasts.

schulich.uwo.ca.Abstract While studies have demonstrated that the main psychoactive component of cannabis, Δ9-tetrahydrocannabinol (Δ9-THC) alone induces placental insufficiency and fetal growth restriction, the underlying mechanisms remain elusive. Given that both (i) endoplasmic reticulum (ER) stress in pregnancy and (ii) gestational exposure to Δ9-THC leads to placental deficiency, we hypothesized that Read more…

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Cannabis use and human retina: The path for the study of brain synaptic transmission dysfunctions in cannabis users.

univ-lorraine.fr.2Pôle Hospitalo-Universitaire de Psychiatrie d’Adultes du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France; INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Département de Psychiatrie, Centre Hospitalier Régional Universitaire de Strasbourg, Strasbourg, France; Maison des Addictions, CHRU Nancy, Nancy, France.3Service d’Ophtalmologie, CHRU Nancy, Nancy, France.4INSERM U1114, Fédération de Médecine Translationnelle Read more…

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Effects of cannabis tetrahydrocannabinol on endocannabinoid homeostasis in human placenta.

ff.up.pt.Abstract Cannabis use has become a hot topic in several countries due to the debate about its legalization for medical purposes. However, data are limited regarding adverse events, safety and potential impact on reproductive health. Cannabis consumption during pregnancy has been associated with gestational disorders such as preterm birth, intrauterine Read more…

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Effects of cannabis tetrahydrocannabinol on endocannabinoid homeostasis in human placenta.

Maia J1, Midão L1,2, Cunha SC3, Almada M1, Fonseca BM1, Braga J4, Gonçalves D4, Teixeira N1, Correia-da-Silva G5.Author information1UCIBIO, REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313, Porto, Portugal.2Departamento de Química, Universidade de Aveiro, Aveiro, Portugal.3LAQV, REQUIMTE, Read more…

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Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells.

korea.ac.kr.6Division of Oncology/Hematology, Department of Internal Medicine, College of Medicine, Korea University Medical Center, Korea University, Seoul, 08308, Republic of Korea; Graduate School of Medicine, College of Medicine, Korea University, Seoul, 08308, Republic of Korea. Electronic address: neogene View the Original article Partage le savoir

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