COVID-19 and Substance Use in Adolescents

Pediatr Clin North Am. 2021 Oct;68(5):977-990. doi: 10.1016/j.pcl.2021.05.005. Epub 2021 May 18. ABSTRACT Studies have yielded mixed findings regarding changes in adolescent substance use during the COVID-19 pandemic; some report increased alcohol and cannabis use, others show less binge drinking and vaping behaviors, and others no change. In 2019, only Read more…

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Targeting of Protein's Messenger RNA for Viral Replication, Assembly and Release in SARS-CoV-2 Using Whole Genomic Data From South Africa: Therapeutic Potentials of Cannabis Sativa L

Front Pharmacol. 2021 Sep 2;12:736511. doi: 10.3389/fphar.2021.736511. eCollection 2021. ABSTRACT The possible evolutionary trend of COVID-19 in South Africa was investigated by comparing the genome of SARS-CoV-2 isolated from a patient in KwaZulu-Natal, South Africa with those isolated from China, Spain, Italy, and United States, as well as the genomes Read more…

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Targeting of Protein's Messenger RNA for Viral Replication, Assembly and Release in SARS-CoV-2 Using Whole Genomic Data From South Africa: Therapeutic Potentials of <em>Cannabis Sativa</em> L

Front Pharmacol. 2021 Sep 2;12:736511. doi: 10.3389/fphar.2021.736511. eCollection 2021. ABSTRACT The possible evolutionary trend of COVID-19 in South Africa was investigated by comparing the genome of SARS-CoV-2 isolated from a patient in KwaZulu-Natal, South Africa with those isolated from China, Spain, Italy, and United States, as well as the genomes Read more…

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Cannabinoid Receptor Type 2 is Upregulated in Synovium following Joint Injury and Mediates Anti-Inflammatory Effects in Synovial Fibroblasts and Macrophages

Osteoarthritis Cartilage. 2021 Sep 16:S1063-4584(21)00888-8. doi: 10.1016/j.joca.2021.09.003. Online ahead of print. ABSTRACT OBJECTIVE: Joint injury-induced perturbations to the endocannabinoid system (ECS), a regulator of both inflammation and nociception, remain largely uncharacterized. We employed a mouse model of ACL rupture to assess alterations to nociception, inflammation, and the ECS while using Read more…

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Reliability of the revised Cochrane risk-of-bias tool for randomised trials (RoB2) improved with the use of implementation instruction

J Clin Epidemiol. 2021 Sep 16:S0895-4356(21)00307-3. doi: 10.1016/j.jclinepi.2021.09.021. Online ahead of print. ABSTRACT OBJECTIVE: to assess the inter-rater reliability (IRR) of the revised Cochrane risk-of-bias tool for randomised trials (RoB2). METHODS: Four raters independently applied RoB2 on critical and important outcomes of individually randomized parallel-group trials (RCTs) included in the Read more…

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Barriers and facilitators to using vaporised nicotine products as smoking cessation aids among people receiving treatment for substance use disorder

Addict Behav. 2021 Aug 24;124:107097. doi: 10.1016/j.addbeh.2021.107097. Online ahead of print. ABSTRACT INTRODUCTION: Vaporised nicotine products (VNPs) may be useful smoking cessation aids for people in alcohol and other drug (AOD) treatment, a population with high tobacco-related morbidity and mortality rates. This qualitative study aimed to examine the barriers and Read more…

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Cannabidiol enhances verbal episodic memory in healthy young participants: A randomized clinical trial

J Psychiatr Res. 2021 Sep 7;143:327-333. doi: 10.1016/j.jpsychires.2021.09.007. Online ahead of print. ABSTRACT Cannabis contains a multitude of different compounds. One of them, cannabidiol – a non-psychoactive substance – might counteract negative effects of Δ-9-Tetrahydrocannabinol on hippocampus-dependent memory impairment. The aim of the present study was to investigate the effect Read more…

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