Gene-environment interaction between an endocannabinoid system genetic polymorphism and cannabis use in first episode of psychosis.

clinic.cat.2Department of Pathological Anatomy, Pharmacology and Microbiology, University of Barcelona, Institutd’InvestigacionsBiomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. CIBERSAM; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.3Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.4Barcelona Clínic Schizophrenia Unit, Hospital Clínic de Barcelona, Barcelona, Read more…

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Gender differences of patients at-risk for psychosis regarding symptomatology, drug use, comorbidity and functioning – Results from the EU-GEI study.

Institute for Health Care Research, Amsterdam, the Netherlands; Parnassia Psychiatric Institute, Department of Psychosis Research, The Hague, the Netherlands.6AMC, Academic Psychiatric Centre, Department Early Psychosis, Amsterdam, the Netherlands; Arkin, Amsterdam, the Netherlands.7Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.8Departament de Psicologia Clínica I de la Salut (Universitat Autònoma Read more…

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The rates and determinants of disengagement and subsequent re-engagement in young people with first-episode psychosis.

orygen.org.au.AbstractBACKGROUND: A core component of treatment provided by early intervention for psychosis (EI) services is ensuring individuals remain successfully engaged with the service. This ensures they can receive the care they may need at this critical early stage of illness. Unfortunately, rates of disengagement are high in individuals with a Read more…

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Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis.

kcl.ac.uk.Abstract The neurobiological mechanisms underlying the association between cannabis use and acute or long-lasting psychosis are not completely understood. While some evidence suggests altered striatal dopamine may underlie the association, direct evidence that cannabis use affects either acute or chronic striatal dopamine is inconclusive. In contrast, pre-clinical research suggests that Read more…

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Effect of cannabis on weight and metabolism in first-episode non-affective psychosis: Results from a three-year longitudinal study.

0.067) than the ‘non-users’ and ‘continuers’. CONCLUSIONS:: The study suggests that cannabis use may produce a protective effect against weight gain and related metabolic alterations in psychosis. However, these results need to be replicated in a larger sample size. KEYWORDS: Cannabis; antipsychotic; cholesterol; first episode psychosis; insulin resistance; medication-naïve; triglycerides; Read more…

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