augusta.edu.2Department of Oral Biology/Dental College of Georgia, Augusta University Medical Center, Augusta, Georgia.3Division of Plastic Surgery/Medical College of Georgia, Department of Surgery, Augusta University Medical Center, Augusta, Georgia.4Department of Oral Biology/Dental College of Georgia, Augusta University Medical Center, Augusta, Georgia; Division of Plastic Surgery/Medical College of Georgia, Department of Surgery, Augusta University Medical Center, Augusta, Georgia.AbstractBACKGROUND:

Malignant melanoma is a complex malignancy with significant morbidity and mortality. The incidence continues to rise, and despite advances in treatment, the prognosis is poor. Thus, it is necessary to develop novel strategies to treat this aggressive cancer. Synthetic cannabinoids have been implicated in inhibiting cancer cell proliferation, reducing tumor growth, and reducing metastasis. We developed a unique study focusing on the effects of treatment with a cannabinoid derivative on malignant melanoma tumors in a murine model.

METHODS:

Murine B16F10 melanoma tumors were established subcutaneously in C57BL/6 mice. Mice were then treated with intraperitoneal injections of vehicle twice per week (control-group 1, n 

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