Regulatory Status of Pesticide Residues in Cannabis: Implications to Medical Use in Neurological Diseases

Curr Res Toxicol. 2021;2:140-148. doi: 10.1016/j.crtox.2021.02.007. Epub 2021 Mar 1. ABSTRACT Medical cannabis represents a potential route of pesticide exposure to susceptible populations. We compared the qualifying conditions for medical use and pesticide testing requirements of cannabis in 33 states and Washington, D.C. Movement disorders were the most common neurological Read more…

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Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome

J Exp Neurol. 2021;2(2):81-85. doi: 10.33696/neurol.2.040. ABSTRACT Dravet Syndrome (DS) is a severe childhood epilepsy caused by heterozygous loss-of-function mutations in the SCN1A gene encoding brain type-I voltage-gated sodium channel Nav1.1. DS is a devastating disease that typically begins at six to nine months of age. Symptoms include recurrent intractable Read more…

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Δ<sup>9</sup>-<em>cis</em>-Tetrahydrocannabinol: Natural Occurrence, Chirality, and Pharmacology

J Nat Prod. 2021 Jul 25. doi: 10.1021/acs.jnatprod.1c00513. Online ahead of print. ABSTRACT The cis-stereoisomers of Δ9-THC [(-)-3 and (+)-3] were identified and quantified in a series of low-THC-containing varieties of Cannabis sativa registered in Europe as fiber hemp and in research accessions of cannabis. While Δ9–cis-THC (3) occurs in Read more…

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Cannabinoids Regulate Sensory Processing in Early Olfactory and Visual Neural Circuits

Front Neural Circuits. 2021 Jul 7;15:662349. doi: 10.3389/fncir.2021.662349. eCollection 2021. ABSTRACT Our sensory systems such as the olfactory and visual systems are the target of neuromodulatory regulation. This neuromodulation starts at the level of sensory receptors and extends into cortical processing. A relatively new group of neuromodulators includes cannabinoids. These Read more…

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