Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients' Perspectives and Attitudes

J Pain Res. 2021 May 5;14:1241-1250. doi: 10.2147/JPR.S278718. eCollection 2021. ABSTRACT INTRODUCTION: Cannabis products have become easily available and accessible after decriminalization of cannabis for recreational and medicinal use in many states. Cannabidiol (CBD) has been of increasing interest to patients and is being used to self-medicate a variety of Read more…

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Screening of key genes and pathways of ischemic stroke and prediction of traditional Chinese medicines based on bioinformatics

Zhongguo Zhong Yao Za Zhi. 2021 Apr;46(7):1803-1812. doi: 10.19540/j.cnki.cjcmm.20210218.401. ABSTRACT The aim of this paper was to explore the key genes and pathogenesis of ischemic stroke(IS) by bioinformatics, and predict the potential traditional Chinese medicines for IS. Based on the gene-chip raw data set of GSE22255 from National Center of Read more…

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ST-segment elevation myocardial infarction with normal coronary arteries secondary to anterior communicating cerebral artery aneurysmal rupture: a case report

Eur Heart J Case Rep. 2021 May 5;5(5):ytab168. doi: 10.1093/ehjcr/ytab168. eCollection 2021 May. ABSTRACT BACKGROUND: Myocardial infarction (MI) with non-obstructive coronary arteries presenting with ST-segment elevation can be challenging. Understanding the cardiac and non-cardiac causes aid in identifying the underlying diagnosis and deciding on the management. Neurological insult resulting in Read more…

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Substance use classes and symptoms of anxiety and depression among Canadian secondary school students

Health Promot Chronic Dis Prev Can. 2021 May;41(5):153-164. doi: 10.24095/hpcdp.41.5.02. ABSTRACT INTRODUCTION: Few studies have assessed patterns of substance use among Canadian adolescents. This cross-sectional study examined substance use classes among Canadian secondary school students and associations with anxiety and depression. METHODS: This study used data from Year 6 (2017/18) Read more…

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Studies of involvement of G-protein coupled receptor-3 in cannabidiol effects on inflammatory responses of mouse primary astrocytes and microglia

PLoS One. 2021 May 13;16(5):e0251677. doi: 10.1371/journal.pone.0251677. eCollection 2021. ABSTRACT Cannabidiol (CBD) exhibits anti-inflammatory and neuroprotective properties and is suggested to be effective in the pre-clinical and clinical treatment of illnesses of the central nervous system (CNS). Two major types of CNS glial cells, astrocytes and microglia, play critical roles Read more…

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Cannabidiol Signaling in the Eye and Its Potential as an Ocular Therapeutic Agent

Cell Physiol Biochem. 2021 May 14;55(S5):1-14. doi: 10.33594/000000371. ABSTRACT Cannabidiol (CBD), the major non-intoxicating constituent of Cannabis sativa, has gained recent attention due to its putative therapeutic uses for a wide variety of diseases. CBD was discovered in the 1940s and its structure fully characterized in the 1960s. However, for Read more…

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Influence of pregabalin maintenance on cannabis effects and related behaviors in daily cannabis users

Exp Clin Psychopharmacol. 2021 May 13. doi: 10.1037/pha0000464. Online ahead of print. ABSTRACT No medications are approved for cannabis use disorder (CUD), though a small clinical trial demonstrated that the voltage-dependent calcium channel (VDCC) ligand gabapentin reduced cannabis use in treatment seekers. VDCCs are modulated by cannabinoid (CB) ligands, and Read more…

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Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device-demonstrative in silico study

PLoS Comput Biol. 2021 May 13;17(5):e1009004. doi: 10.1371/journal.pcbi.1009004. Online ahead of print. ABSTRACT With electronic (e)-liquids containing cannabis components easily available, many anecdotal examples of cannabis vaping using electronic cigarette devices have been reported. For electronic cigarette cannabis vaping, there are potential risks of secondary indoor air pollution from vapers. Read more…

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Naturalistic exploratory study of the associations of substance use on ADHD outcomes and function

BMC Psychiatry. 2021 May 12;21(1):251. doi: 10.1186/s12888-021-03263-6. ABSTRACT BACKGROUND: Although Attention Deficit Hyperactivity Disorder (ADHD) is associated with an increased risk of substance use disorder (SUD), existing literature on how SUD interacts with ADHD outcomes is limited. This study investigates whether SUD among individuals with ADHD is associated with worse Read more…

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