Cannabidiol attenuates aggressive behavior induced by social isolation in mice: Involvement of 5-HT1A and CB1 receptors.

usp.br.3Department of Pharmacology, Medical School of Ribeirão Preto – University of São Paulo (FMRP-USP), 14049-900 Ribeirão Preto, São Paulo, Brazil.Abstract Long-term single housing increases aggressive behavior in mice, a condition named isolation-induced aggression or territorial aggression, which can be attenuated by anxiolytic, antidepressant, and antipsychotic drugs. Preclinical and clinical findings Read more…

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Cannabidiol attenuates aggressive behavior induced by social isolation in mice: Involvement of 5-HT1A and CB1 receptors.

USP.br.3Department de la pharmacologie, l’école médicale de Ribeirão Preto – Université de São Paulo (USP-FMRP) 14049-900 Ribeirão Preto, São Paulo, Brazil.Abstract Logement unique à long terme augmente le comportement agressif chez les souris, une condition nommée agression induite par l’isolement ou l’agression territoriale, qui peut être atténuée par des anxiolytiques, Read more…

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Δ9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions.

Δ9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions.Nguyen JD1, Grant Y1, Creehan KM1, Hwang CS2, Vandewater SA3, Janda KD4, Cole M5, Taffe MA6.Author information1Department of Neuroscience, La Jolla, CA, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.2Department of Chemistry and Immunology, The Skaggs Institute for Read more…

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Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors.

ufpr.br.Abstract Most diabetic patients describe moderate to severe pain symptoms whose pharmacological treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results in painful conditions. Then, we aimed to investigate the potential antinociceptive effect of CBD over the mechanical allodynia in streptozotocin-induced diabetic (DBT) rats, as well as Read more…

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