Novel protective effect of O-1602 and abnormal cannabidiol, GPR55 agonists, on ER stress-induced apoptosis in pancreatic β-cells.

umac.mo.Abstract Insulin resistance and β-cell dysfunction are the main defects in Type 2 Diabetes Mellitus (T2DM), and β-cell dysfunction and apoptosis is the critical determinant in the progression of T2DM. G-protein coupled receptor 55 (GPR55) is an orphan G-protein coupled receptor, which is activated by endocannabinoids and lipid transmitters. Recently, Read more…

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Effect of cannabis on weight and metabolism in first-episode non-affective psychosis: Results from a three-year longitudinal study.

0.067) than the ‘non-users’ and ‘continuers’. CONCLUSIONS:: The study suggests that cannabis use may produce a protective effect against weight gain and related metabolic alterations in psychosis. However, these results need to be replicated in a larger sample size. KEYWORDS: Cannabis; antipsychotic; cholesterol; first episode psychosis; insulin resistance; medication-naïve; triglycerides; Read more…

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The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No « Strain, » No Gain.

Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials Submit Data Resources Chemicals & BioassaysData & SoftwareDNA & RNADomains & StructuresGenes & ExpressionGenetics & MedicineGenomes & MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyVariation Popular PubMed Bookshelf PubMed Central BLAST Nucleotide Genome SNP Gene Protein PubChem Featured Genetic Testing Registry Read more…

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The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No « Strain, » No Gain.

Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials Submit Data Resources Chemicals & BioassaysData & SoftwareDNA & RNADomains & StructuresGenes & ExpressionGenetics & MedicineGenomes & MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyVariation Popular PubMed Bookshelf PubMed Central BLAST Nucleotide Genome SNP Gene Protein PubChem Featured Genetic Testing Registry Read more…

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Exploring the association between initial serum alcohol concentration and polysubstance use: More than a simple « gateway drug » effect?

Jordan A1, Salen P2, Wojda TR3, Cohen MS2, Hasani A4, Luster J4, Seoane J4, Stawicki SP3, Stankewicz H2.Author information1Department of Surgery, St. Luke’s University Health Network, Bethlehem, Pennsylvania, USA.2Department of Emergency Medicine, St. Luke’s University Health Network, Bethlehem, Pennsylvania, USA.3Department of Research and Innovation, St. Luke’s University Health Network, Bethlehem, Read more…

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∆9-Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB1 receptor.

9-Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB1 receptor.Kimura T1, Takaya M1, Usami N1, Watanabe K2, Yamamoto I1.Author information11Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa, 920-1181 Japan.22Center for Supporting Pharmaceutical Education, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Read more…

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