Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice.

Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice.Smoker MP1, Mackie K2, Lapish CC3, Boehm SL 2nd3.Author information1Department of Psychology and Indiana Alcohol Research Center, Indiana University – Purdue University Indianapolis, Indianapolis, IN, 46202, USA. Electronic address: msmoker View the Original article Partage le savoir

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Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.

duke.edu.2Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA.3Department of Obstetrics and Gynecology, Duke University Medical Center, USA.Abstract Developmental neurotoxicity of a wide variety of toxicants mediated via maternal exposure during gestation is very well established. In contrast, the impacts of paternal toxicant exposure on offspring neurobehavioral function Read more…

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Cannabinoid signal transduction explains disconnect of cannabis effects in experimental and clinical colitis.

Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials Submit Data Resources Chemicals & BioassaysData & SoftwareDNA & RNADomains & StructuresGenes & ExpressionGenetics & MedicineGenomes & MapsHomologyLiteratureProteinsSequence AnalysisTaxonomyVariation Popular PubMed Bookshelf PubMed Central BLAST Nucleotide Genome SNP Gene Protein PubChem Featured Genetic Testing Registry Read more…

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Effects of Cannabis Use on Sedation Requirements for Endoscopic Procedures.

.05). The statistical significance persisted when adjusted for age, sex, and use of alcohol, benzodiazepines, and opiates. Conclusion: Determining cannabis use before procedural sedation can be an important tool for planning patient care and assessing both medication needs and possible risks related to increased dosage requirements during endoscopic procedures. PMID: Read more…

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Acute effects of ∆9-tetrahydrocannabinol (THC) on resting state brain function and their modulation by COMT genotype.

umcutrecht.nl.2Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.3Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, Read more…

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Effects of the Psychedelic Amphetamine MDA (3,4-Methylenedioxyamphetamine) in Healthy Volunteers.

741 µg/L for the metabolite 4-hydroxy-3-methoxyamphetamine (HMA). There was considerable between-subject variation in MDA/HMA ratios. The similarity of MDA and MDMA pharmacokinetics suggests that the greater duration of MDA effects is due to pharmacodynamics rather than pharmacokinetics. KEYWORDS: MDMA; Psychedelic; amphetamine; entactogen PMID: 30967099 DOI: 10.1080/02791072.2019.1593560 Share Supplemental Content — Read more…

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Cannabidiol: The Need for More Information About Its Potential Benefits and Side Effects.

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Effects of nicotine and THC vapor inhalation administered by an electronic nicotine delivery system (ENDS) in male rats.

scripps.edu.AbstractBACKGROUND: Electronic nicotine delivery systems (ENDS, e-cigarettes) are increasingly used for the self-administration of nicotine by various human populations, including previously nonsmoking adolescents. Studies in preclinical models are necessary to evaluate health impacts of ENDS including the development of nicotine addiction, effects of ENDS vehicles, flavorants and co-administered psychoactive substances Read more…

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